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DOI:

https://doi.org/10.56612/ijaeb.v1i1.57

Apoptotic potential of geranyl acetate in HepG2 liver cancer cells

Authors

  • Ishfaq Ahmad The University of Lahore

  • Tahir Maqbool IMBB, The university of Lahore

  • Sadia Naz The University of Lahore

  • Inamullah The University of Lahore

  • Faheem Hadi Department of BHMS, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Pakistan.

  • Muhammad Atif The University of Lahore

Abstract

Natural compounds having apoptotic effects are a new potential source for anti-cancer drugs. Numerous plant phytochemicals have proven anti-cancer properties by inducing programmed cell death (apoptosis). The disease known as cancer is characterized by the uncontrollable growth of some body cells and their spread to other body regions. Worldwide, cancer is a major cause of death. The objective of the current study was to assess apoptotic potential of geranyl acetate on HepG2 cancer cell line. Cell death and cell viability in groups were assessed using the MTT, trypan blue and crystal violet to assess anti-proliferative effect. P53 ELISA was carried out to assess apoptosis. When HepG2 cells were exposed to geranyl acetate they exhibited increased cytotoxicity, decreased viability, proliferation, and increased apoptosis. It is concluded that geranyl acetate has the potential to cause apoptosis via P53 in HepG2 cells. It can also prevent cancer cell growth and proliferation.

Author Biographies

Ishfaq Ahmad, The University of Lahore

Institute of Molecular biology and Biotechnology The University of Lahore

Sadia Naz, The University of Lahore

Department of Allied Health Sciences, UOL

Inamullah, The University of Lahore

Institute of Molecular biology and Biotechnology The University of Lahore

Faheem Hadi, Department of BHMS, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Pakistan.

Department of BHMS

Muhammad Atif, The University of Lahore

1Centre of Research in Molecular Medicine, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.

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Published

2023-05-03

How to Cite

Ahmad, I., Maqbool, T., Naz, S., Inamullah, Hadi, F., & Atif, M. (2023). Apoptotic potential of geranyl acetate in HepG2 liver cancer cells. International Journal of Applied and Experimental Biology, 2(2), 89–96. https://doi.org/10.56612/ijaeb.v1i1.57

Issue

Section

Human Biology